Carvedilol dihydrogen phosphate propan-2-ol solvate from powder diffraction data
نویسندگان
چکیده
In the cation of the title compound, C(24)H(27)N(2)O(4) (+)·H(2)PO(4) (-)·C(3)H(8)O [systematic name: 3-(9H-carbazol-4-yl-oxy)-2-hydr-oxy-N-[2-(2-methoxy-phen-oxy)eth-yl]propan-1-aminium dihydro-gen phosphate propan-2-ol solvate], the mean planes of the tricyclic carbazole system and the benzene ring form a dihedral angle of 42.00 (16)°. In the crystal structure, classical inter-molecular O-H⋯O and N-H⋯O hydrogen bonds link the cations, anions and solvent mol-ecules into layers parallel to the ac plane.
منابع مشابه
Carvedilol dihydrogen phosphate hemihydrate: a powder study
IN THE CATION OF THE TITLE COMPOUND [SYSTEMATIC NAME: 3-(9H-carbazol-4-yl-oxy)-2-hydr-oxy-N-[2-(2-methoxy-phen-oxy)eth-yl]propan-1-aminium dihydrogen phosphate hemihydrate], C(24)H(27)N(2)O(4) (+)·H(2)PO(4) (-)·0.5H(2)O, the mean planes of the tricyclic ring system and the benzene ring form a dihedral angle of 87.2 (2)°. In the crystal structure, the solvent water mol-ecule is situated on a two...
متن کامل2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
In the title solvate, C17H20N4S·2C3H8O, pairs of olanzapine mol-ecules related by a centre of inversion stack along the a axis, forming columns, which are packed parallel to each other along the b axis, forming a sheet arrangement. The columns within these sheets are hydrogen bonded to each other through the propan-2-ol solvent mol-ecules. The diazepine ring of the olanzapine exists in a pucker...
متن کامل(9H-Fluoren-9-yl)methyl N-{(2R,3R,4S)-4-hydroxy-2-[(2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-5-oxooxolan-3-yl}carbamate propan-2-ol 0.334-solvate
The title compound, C(29)H(35)NO(6).0.334C(3)H(8)O, a novel chiral N-(fluoren-9-yl-methyl-oxyxcarbon-yl) precursor, crystallizes with two independent carbamate (M) mol-ecules and propan-2-ol solvent mol-ecules in the unit cell. Its crystal structure has been determined from barely adequate data obtained from a multi-fragment needle crystal. In the crystal, N-H⋯O hydrogen bonds link M mol-ecules...
متن کاملChannel-forming solvate crystals and isostructural solvent-free powder of 5-hydroxy-6-methyl-2-pyridone.
Crystals of 5-hydroxy-6-methyl-2-pyridone, (I), grown from a variety of solvents, are invariably trigonal (space group R3); these are 5-hydroxy-6-methyl-2-pyridone acetone 0.1667-solvate, C(6)H(7)NO(2)·0.1667C(3)H(6)O, (Ia), and 6-methyl-5-hydroxy-2-pyridone propan-2-ol 0.1667-solvate, C(6)H(7)NO(2)·0.1667C(3)H(8)O, (Ib), and the forms from methanol, (Ic), water, (Id), benzonitrile, (Ie), and b...
متن کاملAction of acid on oligoribonucleotide phosphotriester intermediates. Effect of released vicinal hydroxy functions.
When 2'-O-methoxytetrahydropyranyl-5'-O-(9-phenylxanthen-9-yl) uridylyl-(3'----5')-(2',3'-di-O-acetyluridine) 2-chlorophenyl ester (9) is treated with zinc bromide in dichloromethane-propan-2-ol (85:15 v/v) at room temperature, under stringently anhydrous conditions, the corresponding 5'-unblocked dinucleoside phosphate (10) is obtained in 86% isolated yield; however, when no special precaution...
متن کامل